My guild is currently progressing at this boss . But we have one major problem : we getting owned by the small adds ( oozes ) .
Our raid setup isn't the best especially the tank classes. So here it is :
on 10m Hc you can kill a bunch of bloods off before you barrel roll after the 1st plate and the 2nd plate. On the 2nd plate, you will need some raid CD / tranq to survive and you shouldn't kill all, try to pick a few off. Amalgamations soak them up right before you roll and fly off with the stacks.
Also now with the dmg reduction it's possible to use defensive CD's (4p) and simply AOE kill a bunch of bloods while you DPS the amalgamation to open the plate. With proper CD´s you won't notice the damage.
Avoid bloods dying while you run in and out of the hole and avoid bloods dying in a too fast frequency without CD's.
Also during the 2nd plate, you can kill more bloods then you need, simple because you kill them one by one and outheal the damage.
A few tips and tricks to keep the blood count low!